CLEC4M, C-type lectin domain family 4 member M

CLEC4M, C-type lectin domain family 4 member M

• This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS infection. [provided by RefSeq, May 2020]

• Gene Synonyms (CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, C-type lectin domain family 4 member M, CD209 antigen-like protein 1, CD299 antigen, DC-SIGN-related protein, dendritic cell-specific ICAM-3-grabbing non-integrin 2, liver/lymph node-specific ICAM-3 grabbing non-integrin, mannose binding C-type lectin DC-SIGNR,)
• NCBI Gene ID: 10332
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4E2Z5
  UNIPROT ID#>>Q9H2X3
  UNIPROT ID#>>H7BXU4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-type lectin domain family 4 member M interacts with:

• CD209 molecule
  C-type lectin domain family 4 member M
  intraflagellar transport 20
  phospholipid phosphatase 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.