MLLT11, MLLT11 transcription factor 7 cofactor

MLLT11, MLLT11 transcription factor 7 cofactor

• The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]

• Gene Synonyms (AF1Q, protein AF1q, ALL1 fused gene from chromosome 1q, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11,)
• NCBI Gene ID: 10962
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13015
  UNIPROT ID#>>Q6FGF7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MLLT11 transcription factor 7 cofactor interacts with:

• argonaute RISC catalytic component 2
  autophagy and beclin 1 regulator 1
  BCL2 like 14
  DnaJ heat shock protein family (Hsp40) member A4
  egl-9 family hypoxia inducible factor 3
  protein tyrosine phosphatase non-receptor type 18
  solute carrier family 15 member 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.