LILRB4, leukocyte immunoglobulin like receptor B4

LILRB4, leukocyte immunoglobulin like receptor B4

• This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CD85K, ILT-3, ILT3, LIR-5, LIR5, leukocyte immunoglobulin-like receptor subfamily B member 4, CD85 antigen-like family member K, immunoglobulin-like transcript 3, leucocyte Ig-like receptor B4, leukocyte immunoglobulin-like receptor 5, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4, monocyte inhibitory receptor HM18,)
• NCBI Gene ID: 11006
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0A0MSZ8
  UNIPROT ID#>>Q8NHJ6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

leukocyte immunoglobulin like receptor B4 interacts with:

• armadillo repeat containing 8
  CD276 molecule
  chromosome 10 open reading frame 88
  GID complex subunit 4 homolog
  GID complex subunit 8 homolog

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.