RNF139, ring finger protein 139

RNF139, ring finger protein 139

• The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]

• Gene Synonyms (E3 ubiquitin-protein ligase RNF139, RING-type E3 ubiquitin transferase RNF139, multiple membrane spanning receptor TRC8, patched related protein translocated in renal cancer, translocation in renal carcinoma on chromosome 8 protein, translocation in renal carcinoma, chromosome 8, HRCA1, RCA1, TRC8,)
• NCBI Gene ID: 11236
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WU17
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 139 interacts with:

• histocompatibility minor 13
  insulin induced gene 2
  SREBF chaperone
  transmembrane and ubiquitin like domain containing 1
  ubiquitin conjugating enzyme E2 U
  ubiquitin conjugating enzyme E2 Z

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.