CTSH, cathepsin H

CTSH, cathepsin H

• The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

• Gene Synonyms (pro-cathepsin H, N-benzoylarginine-beta-naphthylamide hydrolase, aleurain, cathepsin B3, cathepsin BA, ACC-4, ACC-5, ACC4, ACC5, CPSB,)
• NCBI Gene ID: 1512
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P09668
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cathepsin H interacts with:

• 3'(2'), 5'-bisphosphate nucleotidase 1
  5'-3' exoribonuclease 1
  cathepsin L
  coiled-coil domain containing 103
  heat shock protein family D (Hsp60) member 1
  multimerin 1
  non-POU domain containing octamer binding
  POC5 centriolar protein
  solute carrier family 25 member 41
  solute carrier organic anion transporter family member 6A1
  splicing factor 3a subunit 1
  surfactant protein B
  TBC1 domain family member 22B
  tectonic family member 3
  Zic family member 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.