DUSP1, dual specificity phosphatase 1

DUSP1, dual specificity phosphatase 1

• The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]

• Gene Synonyms (CL100, HVH1, MKP-1, MKP1, PTPN10, dual specificity protein phosphatase 1, CL 100, MAP kinase phosphatase 1, dual specificity protein phosphatase hVH1, mitogen-activated protein kinase phosphatase 1, protein-tyrosine phosphatase CL100, serine/threonine specific protein phosphatase,)
• NCBI Gene ID: 1843
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P28562
  UNIPROT ID#>>B4DU40
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dual specificity phosphatase 1 interacts with:

• abhydrolase domain containing 14B
  apoptosis associated tyrosine kinase
  COPI coat complex subunit zeta 1
  dual specificity phosphatase 1
  dual specificity phosphatase 3
  ethylmalonyl-CoA decarboxylase 1
  EYA transcriptional coactivator and phosphatase 2
  F-box protein 32
  HD domain containing 2
  heat shock protein family A (Hsp70) member 4
  heat shock protein family B (small) member 2
  inhibitor of nuclear factor kappa B kinase subunit beta
  isoprenylcysteine carboxyl methyltransferase
  methionine adenosyltransferase 2A
  microtubule associated protein tau
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 10
  mitogen-activated protein kinase 12
  mitogen-activated protein kinase 3
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase 9
  myotubularin related protein 12
  NADH:ubiquinone oxidoreductase subunit A13
  Parkinsonism associated deglycase
  proteasome 20S subunit alpha 1
  proteasome 26S subunit, non-ATPase 1
  protein kinase C iota
  protein tyrosine phosphatase non-receptor type 1
  receptor tyrosine kinase like orphan receptor 2
  RNA polymerase I subunit H
  sorting nexin 17
  spermidine synthase
  S-phase kinase associated protein 2
  transmembrane protein 97
  ubiquitin B
  ubiquitin specific peptidase 49

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.