EDNRA, endothelin receptor type A

EDNRA, endothelin receptor type A

• This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

• Gene Synonyms (ET-A, ETA, ETA-R, ETAR, ETRA, MFDA, hET-AR, endothelin-1 receptor, G protein-coupled receptor, endothelin receptor subtype A, endothelin-1-specific receptor,)
• NCBI Gene ID: 1909
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P25101
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

endothelin receptor type A interacts with:

• ADP ribosylation factor like GTPase 5B
  BCL2 like 11
  COP9 signalosome subunit 5
  EBP cholestenol delta-isomerase
  G protein subunit alpha 11
  G protein subunit alpha i2
  G protein-coupled receptor kinase 6
  histone deacetylase 7
  limb development membrane protein 1
  lysine acetyltransferase 5
  MCL1 apoptosis regulator, BCL2 family member
  metaxin 1
  mitochondrially encoded cytochrome c oxidase I
  mitochondrially encoded NADH dehydrogenase 1
  peroxisomal membrane protein 2
  solute carrier family 5 member 3
  SRC proto-oncogene, non-receptor tyrosine kinase
  synaptogyrin 2
  vitamin K epoxide reductase complex subunit 1 like 1
  VPS11 core subunit of CORVET and HOPS complexes

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.