MLKL, mixed lineage kinase domain like pseudokinase

MLKL, mixed lineage kinase domain like pseudokinase

• This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]

• Gene Synonyms (mixed lineage kinase domain-like protein, hMLKL,)
• NCBI Gene ID: 197259
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8NB16
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mixed lineage kinase domain like pseudokinase interacts with:

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