EPOR, erythropoietin receptor

EPOR, erythropoietin receptor

• This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

• Gene Synonyms (EPO-R, erythropoietin receptor, truncated erythropoietin receptor,)
• NCBI Gene ID: 2057
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P19235
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

erythropoietin receptor interacts with:

• ataxin 2 like
  beta-transducin repeat containing E3 ubiquitin protein ligase
  cullin 2
  egl-9 family hypoxia inducible factor 3
  elongin B
  elongin C
  erythropoietin receptor
  F-box and WD repeat domain containing 7
  G protein subunit alpha i1
  GRB2 associated binding protein 1
  GRB2 associated binding protein 2
  GRB2 related adaptor protein
  growth factor receptor bound protein 2
  inositol polyphosphate-5-phosphatase D
  insulin receptor substrate 2
  Janus kinase 2
  KIT ligand
  KIT proto-oncogene, receptor tyrosine kinase
  LYN proto-oncogene, Src family tyrosine kinase
  macrophage stimulating 1 receptor
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  nitric oxide synthase interacting protein
  phosphoinositide-3-kinase regulatory subunit 1
  phospholipase C gamma 1
  phospholipase C gamma 2
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 6
  receptor for activated C kinase 1
  SH2B adaptor protein 2
  SHC adaptor protein 1
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 5B
  spleen associated tyrosine kinase
  SRC proto-oncogene, non-receptor tyrosine kinase
  suppressor of cytokine signaling 2
  suppressor of cytokine signaling 3
  vav guanine nucleotide exchange factor 1
  von Hippel-Lindau tumor suppressor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.