F13A1, coagulation factor XIII A chain

F13A1, coagulation factor XIII A chain

• This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

• Gene Synonyms (F13A, coagulation factor XIII A chain, FSF, A subunit, TGase, bA525O21.1 (coagulation factor XIII, A1 polypeptide), coagulation factor XIII, A polypeptide, coagulation factor XIII, A1 polypeptide, coagulation factor XIIIa, factor XIIIa, fibrin stabilizing factor, A subunit, fibrinoligase, protein-glutamine gamma-glutamyltransferase A chain, transglutaminase A chain, transglutaminase. plasma,)
• NCBI Gene ID: 2162
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P00488
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

coagulation factor XIII A chain interacts with:

• coagulation factor XIII A chain
  coagulation factor XIII B chain
  fibrinogen alpha chain
  fibrinogen gamma chain
  fibronectin 1
  nudix hydrolase 21
  protein tyrosine kinase 2
  serpin family F member 2
  SH3 domain containing GRB2 like 2, endophilin A1
  thymidine kinase 1
  ubiquitin recognition factor in ER associated degradation 1

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