FAP, fibroblast activation protein alpha

FAP, fibroblast activation protein alpha

• The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

• Gene Synonyms (DPPIV, FAPA, FAPalpha, SIMP, prolyl endopeptidase FAP, 170 kDa melanoma membrane-bound gelatinase, dipeptidyl peptidase FAP, gelatine degradation protease FAP, integral membrane serine protease, post-proline cleaving enzyme, seprase, surface-expressed protease,)
• NCBI Gene ID: 2191
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q12884
  UNIPROT ID#>>B4DLR2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

fibroblast activation protein alpha interacts with:

• coronin 1C
  ER lipid raft associated 2
  fibroblast activation protein alpha
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  methionine sulfoxide reductase B1
  plasminogen activator, urokinase receptor
  prohibitin
  prohibitin 2
  RNA binding motif protein 3
  RNA binding motif protein 4
  SH3 domain containing kinase binding protein 1
  Thy-1 cell surface antigen
  transmembrane protein 109

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.