AFF2, AF4/FMR2 family member 2

AFF2, AF4/FMR2 family member 2

• This gene encodes a putative transcriptional activator that is a member of the AF4\FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked cognitive disability. In addition, this gene contains 6-25 GCC repeats that are expanded to >200 repeats in the disease state. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2016]

• Gene Synonyms (FMR2, FMR2P, FRAXE, MRX2, OX19, AF4/FMR2 family member 2, fragile X E mental retardation syndrome protein, fragile X mental retardation 2 protein, protein FMR-2,)
• NCBI Gene ID: 2334
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51816
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

AF4/FMR2 family member 2 interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  PHD finger protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.