SCRIB, scribble planar cell polarity protein

SCRIB, scribble planar cell polarity protein

• This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

• Gene Synonyms (protein scribble homolog, scribbled homolog, scribbled planar cell polarity protein, CRIB1, SCRB1, SCRIB1, Vartul,)
• NCBI Gene ID: 23513
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0PJK8
  UNIPROT ID#>>Q14160
  UNIPROT ID#>>A0A0G2JNZ2
  UNIPROT ID#>>A0A0G2JPP5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

scribble planar cell polarity protein interacts with:

• centrosomal protein 19
  coiled-coil domain containing 8
  C-type lectin domain family 18 member A
  defective in cullin neddylation 1 domain containing 1
  egl-9 family hypoxia inducible factor 3
  Fas binding factor 1
  forkhead box B1
  forkhead box K1
  leucine rich repeat containing 27
  leucine rich repeat containing 6
  leucine rich repeat containing G protein-coupled receptor 4
  leucine rich repeats and immunoglobulin like domains 1
  limb development membrane protein 1 like
  mediator complex subunit 4
  nucleoporin 107
  pleckstrin homology domain containing A4
  prolyl 4-hydroxylase subunit alpha 3
  ring finger protein 123
  ring finger protein 146
  ring finger protein 213
  RNA binding motif protein 23
  Shoc2, leucine rich repeat scaffold protein
  transmembrane protein 17
  trimethylguanosine synthase 1
  vir like m6A methyltransferase associated
  VPS11 core subunit of CORVET and HOPS complexes
  zinc finger and BTB domain containing 44

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.