GPT, glutamic--pyruvic transaminase

GPT, glutamic--pyruvic transaminase

• This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]

• Gene Synonyms (alanine aminotransferase 1, alanine aminotransferase, alanine transaminase, glutamate pyruvate transaminase 1, glutamic--pyruvic transaminase 1, glutamic-alanine transaminase 1, glutamic-pyruvate transaminase (alanine aminotransferase), AAT1, ALT1, GPT1,)
• NCBI Gene ID: 2875
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P24298
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glutamic--pyruvic transaminase interacts with:

• cell division cycle 7
  RAS like proto-oncogene A
  SAS-6 centriolar assembly protein

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