GSTM4, glutathione S-transferase mu 4

GSTM4, glutathione S-transferase mu 4

• Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (glutathione S-transferase Mu 4, GST class-mu 4, GST-Mu2, GTS-Mu2, S-(hydroxyalkyl)glutathione lyase M4, glutathione S-alkyltransferase M4, glutathione S-aralkyltransferase M4, glutathione S-aryltransferase M4, glutathione S-transferase M4, leukotriene C4 synthase GSTM4, testis tissue sperm-binding protein Li 60n, GSTM4-4, GTM4,)
• NCBI Gene ID: 2948
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VKE3
  UNIPROT ID#>>Q03013
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glutathione S-transferase mu 4 interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  BAG cochaperone 3
  glutathione S-transferase mu 4
  glutathione S-transferase mu 5
  HEXIM P-TEFb complex subunit 1
  immunoglobin superfamily member 21
  ligand dependent nuclear receptor interacting factor 1
  mediator complex subunit 31
  negative elongation factor complex member C/D
  TLE family member 1, transcriptional corepressor
  tumor protein p53
  unc-119 lipid binding chaperone
  zinc finger and BTB domain containing 16

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.