- Gene Overview
- Interaction Network
- Sequence Verification
GUCY2D, guanylate cyclase 2D, retinal
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This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]
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Gene Synonyms (retinal guanylyl cyclase 1, ROS-GC, cone rod dystrophy 6, guanylate cyclase 2D, membrane (retina-specific), retinal guanylate cyclase 1, rod outer segment membrane guanylate cyclase, CACD1, CG-E, CORD5, CORD6, CSNB1I, CYGD, GUC1A4, GUC2D, LCA, LCA1, RCD2, RETGC-1, ROS-GC1, ROSGC, retGC,)
- NCBI Gene ID:
3000
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q02846
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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guanylate cyclase 2D, retinal interacts with:
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