IL5RA, interleukin 5 receptor subunit alpha

IL5RA, interleukin 5 receptor subunit alpha

• The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

• Gene Synonyms (interleukin-5 receptor subunit alpha, CD125 antigen, IL-5 receptor subunit alpha, IL-5R subunit alpha, interleukin 5 receptor type 3, interleukin 5 receptor, alpha, interleukin-5 receptor alpha chain, CD125, CDw125, HSIL5R3, IL5R,)
• NCBI Gene ID: 3568
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q01344
  UNIPROT ID#>>Q8NHV7
  UNIPROT ID#>>A0A024R2C8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interleukin 5 receptor subunit alpha interacts with:

• interleukin 5 receptor subunit alpha
  Janus kinase 1
  Janus kinase 2
  syndecan binding protein
  unc-119 lipid binding chaperone

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