LEP, leptin

LEP, leptin

• This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Aug 2017]

• Gene Synonyms (LEPD, OB, OBS, leptin, leptin (murine obesity homolog), leptin (obesity homolog, mouse), obese protein, obese, mouse, homolog of, obesity factor,)
• NCBI Gene ID: 3952
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A4D0Y8
  UNIPROT ID#>>P41159
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

leptin interacts with:

• ghrelin and obestatin prepropeptide
  heat shock transcription factor 2 binding protein
  leptin receptor
  leptin receptor
  protein kinase AMP-activated catalytic subunit alpha 2
  urocortin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.