MYH6, myosin heavy chain 6

MYH6, myosin heavy chain 6

• Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located approximately 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. [provided by RefSeq, Feb 2017]

• Gene Synonyms (ASD3, CMD1EE, CMH14, MYHC, MYHCA, SSS3, alpha-MHC, myosin-6, myHC-alpha, myosin heavy chain, cardiac muscle alpha isoform, myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1),)
• NCBI Gene ID: 4624
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P13533
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

myosin heavy chain 6 interacts with:

• B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
  BAG cochaperone 3
  breast cancer 1, early onset
  bromodomain containing 1
  calcium binding and coiled-coil domain 1
  calcium binding and coiled-coil domain 2
  COPI coat complex subunit epsilon
  DDB1 and CUL4 associated factor 1
  dedicator of cytokinesis 6
  elongin C
  erythroid differentiation regulatory factor 1
  F-box protein 31
  ITPRIP like 2
  minichromosome maintenance complex component 3 associated protein
  mitogen-activated protein kinase kinase 3
  MYB binding protein 1a
  myosin heavy chain 6
  myosin light chain 7
  N-ethylmaleimide sensitive factor, vesicle fusing ATPase
  optineurin
  phosphatidylinositol glycan anchor biosynthesis class S
  RNA polymerase II subunit A
  sortilin 1
  spindle and centriole associated protein 1
  SPT2 chromatin protein domain containing 1
  thymosin beta 4 X-linked
  thyroid hormone receptor interactor 11
  transmembrane protein 132A
  tripartite motif containing 63
  tropomyosin 1
  tropomyosin 2
  troponin I1, slow skeletal type
  ubiquitin specific peptidase 24
  uridine monophosphate synthetase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.