OPHN1, oligophrenin 1

OPHN1, oligophrenin 1

• This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked cognitive disability with cerebellar hypoplasia and distinctive facial dysmorhphism. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ARHGAP41, MRX60, OPN1, oligophrenin-1, mental retardation, X-linked 60, oligophrenin-1, Rho-GTPase activating protein,)
• NCBI Gene ID: 4983
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60890
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

oligophrenin 1 interacts with:

• nuclear RNA export factor 1
  Rac family small GTPase 1
  Rho GTPase activating protein 26
  tripartite motif containing 25
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.