FURIN, furin, paired basic amino acid cleaving enzyme

FURIN, furin, paired basic amino acid cleaving enzyme

• This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2020]

• Gene Synonyms (FUR, PACE, PCSK3, SPC1, furin, FES upstream region, dibasic processing enzyme, furin, membrane associated receptor protein, paired basic amino acid residue-cleaving enzyme, proprotein convertase subtilisin/kexin type 3,)
• NCBI Gene ID: 5045
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P09958
  UNIPROT ID#>>A0A024RC70
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

furin, paired basic amino acid cleaving enzyme interacts with:

• 2-phosphoxylose phosphatase 1
  ADAM metallopeptidase domain 19
  ADAM metallopeptidase with thrombospondin type 1 motif 1
  ADAM metallopeptidase with thrombospondin type 1 motif 4
  BAG cochaperone 6
  beta-secretase 1
  chondromodulin
  collagen type XXIII alpha 1 chain
  DENN/MADD domain containing 6A
  filamin, alpha
  furin, paired basic amino acid cleaving enzyme
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  integral membrane protein 2C
  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
  phosphofurin acidic cluster sorting protein 1
  platelet derived growth factor subunit A
  proline rich protein BstNI subfamily 4
  pro-melanin concentrating hormone
  serpin family A member 5
  serpin family B member 8
  small glutamine rich tetratricopeptide repeat containing beta
  sortilin related receptor 1
  sortilin related VPS10 domain containing receptor 1
  TNF superfamily member 13
  von Willebrand factor
  zona pellucida glycoprotein 3
  zona pellucida glycoprotein 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.