ACSL5, acyl-CoA synthetase long chain family member 5

ACSL5, acyl-CoA synthetase long chain family member 5

• The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (long-chain-fatty-acid--CoA ligase 5, FACL5 for fatty acid coenzyme A ligase 5, LACS 5, arachidonate--CoA ligase, fatty acid coenzyme A ligase 5, fatty-acid-Coenzyme A ligase, long-chain 5, long-chain acyl-CoA synthetase 5, long-chain fatty acid coenzyme A ligase 5, ACS2, ACS5, FACL5,)
• NCBI Gene ID: 51703
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9ULC5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

acyl-CoA synthetase long chain family member 5 interacts with:

• coenzyme Q9
  family with sequence similarity 136 member A
  reticulophagy regulator family member 3
  selenoprotein I
  solute carrier family 10 member 6
  solute carrier family 7 member 14
  transmembrane protein 14B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.