PTPA, protein phosphatase 2 phosphatase activator

PTPA, protein phosphatase 2 phosphatase activator

• Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

• Gene Synonyms (serine/threonine-protein phosphatase 2A activator, PP2A phosphatase activator, PP2A subunit B' isoform PR53, phosphotyrosyl phosphatase activator, protein phosphatase 2 regulatory subunit 4, protein phosphatase 2A activator, regulatory subunit 4, protein phosphatase 2A regulatory subunit 4, protein phosphatase 2A, regulatory subunit B' (PR 53), serine/threonine-protein phosphatase 2A regulatory subunit B', PP2A, PPP2R4, PR53,)
• NCBI Gene ID: 5524
• Species: Homo sapiens (Human)
• UNIPROT ID#>>F6WIT2
  UNIPROT ID#>>B4DZF8
  UNIPROT ID#>>Q15257
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein phosphatase 2 phosphatase activator interacts with:

• acyl-CoA thioesterase 13
  angiomotin
  anterior gradient 2, protein disulphide isomerase family member
  aurora kinase B
  basic helix-loop-helix family member b9
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  coiled-coil domain containing 125
  D-aminoacyl-tRNA deacylase 1
  family with sequence similarity 110 member C
  glutamate ionotropic receptor NMDA type subunit 3A
  histone deacetylase 4
  histone deacetylase 6
  immediate early response 3
  KISS1 receptor
  mitogen-activated protein kinase kinase 3
  myocardin
  myosin light chain, phosphorylatable, fast skeletal muscle
  NGG1 interacting factor 3 like 1
  nuclear RNA export factor 1
  phosphatase and tensin homolog
  phosphohistidine phosphatase 1
  protein kinase C beta
  protein phosphatase 4 catalytic subunit
  protein phosphatase 4 regulatory subunit 2
  protein phosphatase 4 regulatory subunit 3A
  Rac GTPase activating protein 1
  ribonucleic acid export 1
  RIKEN cDNA 4932438A13 gene
  serine/threonine kinase 26
  SET nuclear proto-oncogene
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  Sp1 transcription factor
  Sp3 transcription factor
  SPG21 abhydrolase domain containing, maspardin
  SRC proto-oncogene, non-receptor tyrosine kinase
  sulfotransferase family 4A member 1
  t-complex 1
  tripartite motif containing 25
  tubulin alpha 1a
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.