PRLR, prolactin receptor

PRLR, prolactin receptor

• This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]

• Gene Synonyms (prolactin receptor, hPRL receptor, secreted prolactin binding protein, HPRL, MFAB, RI-PRLR, hPRLrI,)
• NCBI Gene ID: 5618
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P16471
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

prolactin receptor interacts with:

• beta-transducin repeat containing E3 ubiquitin protein ligase
  F-box and WD repeat domain containing 11
  insulin induced gene 2
  phospholipid phosphatase 6
  prolactin receptor
  protein tyrosine phosphatase non-receptor type 11
  signal transducer and activator of transcription 5B
  suppressor of cytokine signaling 2
  suppressor of cytokine signaling 3
  tec protein tyrosine kinase
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  vav guanine nucleotide exchange factor 1
  vav guanine nucleotide exchange factor 2
  vir like m6A methyltransferase associated
  zeta chain of T cell receptor associated protein kinase 70

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.