PRNP, prion protein

PRNP, prion protein

• The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

• Gene Synonyms (major prion protein, alternative prion protein, CD230 antigen, prion-related protein, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30,)
• NCBI Gene ID: 5621
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P04156
  UNIPROT ID#>>F7VJQ1
  UNIPROT ID#>>Q53YK7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

prion protein interacts with:

• activator of basal transcription 1
  ADAM metallopeptidase domain 23
  apoptosis inducing factor mitochondria associated 3
  ArfGAP with dual PH domains 2
  argonaute RISC component 1
  BAG cochaperone 6
  bromodomain adjacent to zinc finger domain 2B
  calsyntenin 1
  chromosome 7 open reading frame 50
  coiled-coil domain containing 149
  CWC15 spliceosome associated protein homolog
  DEAD-box helicase 47
  dedicator of cytokinesis 7
  dipeptidylpeptidase 6
  dual specificity tyrosine phosphorylation regulated kinase 3
  ERI1 exoribonuclease family member 3
  F-box protein 45
  fibulin 5
  HCLS1 associated protein X-1
  huntingtin
  immediate early response 3
  KIAA1191
  kinesin associated protein 3
  metabolism of cobalamin associated D
  microtubule affinity regulating kinase 4
  mitochondrial ribosome associated GTPase 1
  nectin cell adhesion molecule 1
  NHP2 ribonucleoprotein
  NIN1 (RPN12) binding protein 1 homolog
  peptidyl-tRNA hydrolase 1 homolog
  phosphodiesterase 4D interacting protein
  PICALM interacting mitotic regulator
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  poly(A) specific ribonuclease subunit PAN2
  PPFIA binding protein 2
  proteasome 20S subunit alpha 3
  proteasome 20S subunit beta 5
  proteasome 26S subunit, non-ATPase 2
  protein phosphatase 1 regulatory inhibitor subunit 14A
  PYM homolog 1, exon junction complex associated factor
  Rho GTPase activating protein 15
  ribosomal protein L41
  ring finger protein 4
  RNA binding motif protein 22
  RNA binding region (RNP1, RRM) containing 3
  SEC31 homolog A, COPII coat complex component
  serine/arginine repetitive matrix 2
  sodium channel modifier 1
  SPARC like 1
  StAR related lipid transfer domain containing 5
  stress induced phosphoprotein 1
  surfeit 2
  TATA-box binding protein like 1
  thymic stromal lymphopoietin
  transmembrane protein 237
  tripartite motif containing 15
  TSC22 domain family member 4
  TYMS opposite strand
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  UTP4 small subunit processome component
  WD repeat domain 5
  WD repeat domain 61
  zinc finger BED-type containing 3
  zinc finger FYVE-type containing 28
  zinc finger protein 408
  zinc finger protein 740
  zinc finger with KRAB and SCAN domains 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.