RAD1, RAD1 checkpoint DNA exonuclease

RAD1, RAD1 checkpoint DNA exonuclease

• This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]

• Gene Synonyms (cell cycle checkpoint protein RAD1, DNA repair exonuclease REC1, DNA repair exonuclease rad1 homolog, RAD1 checkpoint clamp component, RAD1 homolog, cell cycle checkpoint protein Hrad1, checkpoint control protein HRAD1, exonuclease homolog RAD1, rad1-like DNA damage checkpoint protein, HRAD1, REC1,)
• NCBI Gene ID: 5810
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R045
  UNIPROT ID#>>O60671
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RAD1 checkpoint DNA exonuclease interacts with:

• COP9 signalosome subunit 5
  DNA topoisomerase II binding protein 1
  DnaJ heat shock protein family (Hsp40) member C7
  HUS1 checkpoint clamp component B
  microtubule associated protein 1 light chain 3 beta
  nei like DNA glycosylase 1
  RAD1 checkpoint DNA exonuclease
  RAD17 checkpoint clamp loader component
  RAD9 checkpoint clamp component A
  RAD9 checkpoint clamp component B
  RAD9-HUS1-RAD1 interacting nuclear orphan 1
  replication factor C subunit 4
  replication factor C subunit 5
  replication protein A1
  replication protein A2
  sirtuin 6
  thymine DNA glycosylase
  tumor protein p53 binding protein 1
  WRN RecQ like helicase
  zinc finger and BTB domain containing 14

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.