MAP4K2, mitogen-activated protein kinase kinase kinase kinase 2

MAP4K2, mitogen-activated protein kinase kinase kinase kinase 2

• The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

• Gene Synonyms (mitogen-activated protein kinase kinase kinase kinase 2, B lymphocyte serine/threonine protein kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, MEKKK 2, Rab8 interacting protein, germinal centre kinase (GC kinase), BL44, GCK, RAB8IP,)
• NCBI Gene ID: 5871
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q12851
  UNIPROT ID#>>A0A024R567
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase kinase kinase 2 interacts with:

• mitogen-activated protein kinase kinase 4
  NAC alpha domain containing
  peroxiredoxin 4
  protection of telomeres 1
  small nuclear ribonucleoprotein U11/U12 subunit 35
  TNF receptor associated factor 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.