RAC2, Rac family small GTPase 2

RAC2, Rac family small GTPase 2

• This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

• Gene Synonyms (ras-related C3 botulinum toxin substrate 2, Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2), ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), small G protein, EN-7, Gx, HSPC022, p21-Rac2,)
• NCBI Gene ID: 5880
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P15153
  UNIPROT ID#>>V9H0H7
  UNIPROT ID#>>A0A024R1P2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rac family small GTPase 2 interacts with:

• ADAM metallopeptidase domain 22
  ADP ribosylation factor interacting protein 2
  AFG3 like matrix AAA peptidase subunit 2
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
  cullin 1
  DEF6 guanine nucleotide exchange factor
  engulfment and cell motility 2
  F-box protein 6
  histone deacetylase 10
  histone deacetylase 7
  isoprenylcysteine carboxyl methyltransferase
  NADPH oxidase activator 1
  nuclear receptor subfamily 2 group C member 2
  pleckstrin homology domain containing A2
  Rac family small GTPase 3
  Rap1 GTPase-GDP dissociation stimulator 1
  rhotekin
  U2 small nuclear RNA auxiliary factor 2
  vascular cell adhesion molecule 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.