RAD9A, RAD9 checkpoint clamp component A

RAD9A, RAD9 checkpoint clamp component A

• This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

• Gene Synonyms (cell cycle checkpoint control protein RAD9A, DNA repair exonuclease rad9 homolog A, RAD9 homolog A, hRAD9, RAD9,)
• NCBI Gene ID: 5883
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99638
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RAD9 checkpoint clamp component A interacts with:

• ATPase family AAA domain containing 5
  centrin 2
  checkpoint kinase 2
  claspin
  COP9 signalosome subunit 5
  DNA topoisomerase II binding protein 1
  DnaJ heat shock protein family (Hsp40) member C7
  envoplakin
  fem-1 homolog B
  HUS1 checkpoint clamp component
  HUS1 checkpoint clamp component B
  intersectin 2
  mutY DNA glycosylase
  nei like DNA glycosylase 1
  RAD17 checkpoint clamp loader component
  RAD9 checkpoint clamp component A
  RAD9 checkpoint clamp component B
  RAD9-HUS1-RAD1 interacting nuclear orphan 1
  replication factor C subunit 5
  replication protein A1
  replication protein A2
  SET domain and mariner transposase fusion gene
  sirtuin 6
  spastin
  splicing factor 3b subunit 3
  thymine DNA glycosylase
  tousled like kinase 1
  tripartite motif containing 25
  tumor protein p53 binding protein 1
  twinkle mtDNA helicase
  WRN RecQ like helicase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.