RAPSN, receptor associated protein of the synapse

RAPSN, receptor associated protein of the synapse

• This gene encodes a member of a family of proteins that are receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site, and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic sites by linking the receptors to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]

• Gene Synonyms (43 kDa receptor-associated protein of the synapse, 43 kda postsynaptic protein, RING finger protein 205, acetylcholine receptor-associated 43 kda protein, CMS11, CMS4C, FADS, FADS2, RAPSYN, RNF205,)
• NCBI Gene ID: 5913
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13702
  UNIPROT ID#>>A0A0S2Z4A2
  UNIPROT ID#>>A0A0S2Z4F8
  UNIPROT ID#>>A0A0S2Z4M9
  UNIPROT ID#>>A0A0S2Z4A6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

receptor associated protein of the synapse interacts with:

• BAG cochaperone 3
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  kelch like family member 8
  KH RNA binding domain containing, signal transduction associated 1
  ubiquitin conjugating enzyme E2 Z

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.