KDM5A, lysine demethylase 5A

KDM5A, lysine demethylase 5A

• This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]

• Gene Synonyms (lysine-specific demethylase 5A, Jumonji, AT rich interactive domain 1A (RBP2-like), [histone H3]-trimethyl-L-lysine(4) demethylase 5A, histone demethylase JARID1A, jumonji/ARID domain-containing protein 1A, lysine (K)-specific demethylase 5A, retinoblastoma binding protein 2, RBBP-2, RBBP2, RBP2,)
• NCBI Gene ID: 5927
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P29375
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lysine demethylase 5A interacts with:

• bromodomain containing 2
  bromodomain containing 8
  embryonic ectoderm development
  EMSY transcriptional repressor, BRCA2 interacting
  GATA zinc finger domain containing 1
  H3 clustered histone 15
  H3.4 histone
  H4 clustered histone 1
  inhibitor of growth family member 3
  La ribonucleoprotein 7, transcriptional regulator
  lysine demethylase 6A
  mortality factor 4 like 1
  mortality factor 4 like 2
  nuclear receptor binding SET domain protein 1
  nuclear receptor subfamily 2 group C member 2
  PHD finger protein 12
  RB binding protein 7, chromatin remodeling factor
  RB transcriptional corepressor like 1
  regulator of chromosome condensation 1
  RNA binding motif protein 8a
  SIN3 transcription regulator family member B
  SUZ12 polycomb repressive complex 2 subunit
  TATA-box binding protein
  transmembrane 9 superfamily member 4
  tripartite motif containing 25
  vir like m6A methyltransferase associated
  vitamin D receptor
  zinc finger protein 131

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.