RDH5, retinol dehydrogenase 5

RDH5, retinol dehydrogenase 5

• This gene encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments. Mutations in this gene cause autosomal recessive fundus albipunctatus, a rare form of night blindness that is characterized by a delay in the regeneration of cone and rod photopigments. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S1 (biogenesis of lysosomal organelles complex-1, subunit 1) gene. [provided by RefSeq, Dec 2010]

• Gene Synonyms (retinol dehydrogenase 5, 11-cis RDH, 11-cis RoDH, 9-cis retinol dehydrogenase, 9-cis-retinol specific dehydrogenase, retinol dehydrogenase 1, retinol dehydrogenase 5 (11-cis and 9-cis), retinol dehydrogenase 5 (11-cis/9-cis), short chain dehydrogenase/reductase family 9C member 5, 9cRDH, HSD17B9, RDH1, SDR9C5,)
• NCBI Gene ID: 5959
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RB18
  UNIPROT ID#>>Q92781
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

retinol dehydrogenase 5 interacts with:

• DNA damage inducible 1 homolog 2
  glucosamine-phosphate N-acetyltransferase 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 3
  retinal G protein coupled receptor
  retinaldehyde binding protein 1
  retinol dehydrogenase 5
  ubiquitin conjugating enzyme E2 G1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.