- Gene Overview
- Interaction Network
- Sequence Verification
TEF, TEF transcription factor, PAR bZIP family member
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This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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Gene Synonyms (thyrotroph embryonic factor, TEF, PAR bZIP transcription factor, thyrotrophic embryonic factor,)
- NCBI Gene ID:
7008
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q10587
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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TEF transcription factor, PAR bZIP family member interacts with:
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