TSG101, tumor susceptibility 101

TSG101, tumor susceptibility 101

• The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]

• Gene Synonyms (tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, tumor susceptibility gene 10, tumor susceptibility gene 101, tumor susceptibility protein, TSG10, VPS23,)
• NCBI Gene ID: 7251
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99816
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tumor susceptibility 101 interacts with:

• acetoacetyl-CoA synthetase
  ADP ribosylation factor GTPase activating protein 2
  ajuba LIM protein
  A-kinase anchoring protein 9
  ALG2 alpha-1,3/1,6-mannosyltransferase
  ankyrin repeat, SAM and basic leucine zipper domain containing 1
  apoptosis antagonizing transcription factor
  argonaute RISC catalytic component 2
  arrestin domain containing 1
  BAG cochaperone 4
  BAG cochaperone 6
  BCAR1 scaffold protein, Cas family member
  BCAS3 microtubule associated cell migration factor
  bromodomain and PHD finger containing 3
  cancer antigen 1
  CCR4-NOT transcription complex subunit 7
  CD2 associated protein
  CD2-associated protein
  CDP-diacylglycerol synthase 2
  centrosomal protein 55
  centrosomal protein 55
  centrosomal protein 63
  charged multivesicular body protein 4B
  charged multivesicular body protein 5
  charged multivesicular body protein 6
  chibby family member 1, beta catenin antagonist
  cleavage and polyadenylation specific factor 7
  coiled-coil alpha-helical rod protein 1
  coiled-coil domain containing 88B
  cyclic GMP-AMP synthase
  DAZ interacting zinc finger protein 3
  DMRT like family B with proline rich C-terminal 1
  DNA methyltransferase 1 associated protein 1
  egl-9 family hypoxia inducible factor 3
  exportin 1
  family with sequence similarity 110 member A
  family with sequence similarity 9 member B
  germ cell-less 1, spermatogenesis associated
  golgi associated, gamma adaptin ear containing, ARF binding protein 1
  golgi associated, gamma adaptin ear containing, ARF binding protein 3
  golgi membrane protein 1
  HAUS augmin like complex subunit 1
  hematopoietic SH2 domain containing
  hepatocyte growth factor-regulated tyrosine kinase substrate
  heterogeneous nuclear ribonucleoprotein U like 1
  huntingtin interacting protein 1 related
  inhibitor of CDK, cyclin A1 interacting protein 1
  IQ motif containing GTPase activating protein 1
  kallikrein related peptidase 5
  keratin 75
  KIAA1328
  La ribonucleoprotein 1, translational regulator
  leucine rich repeat and sterile alpha motif containing 1
  leukocyte receptor cluster member 8
  ligand of numb-protein X 1
  lipopolysaccharide induced TNF factor
  mahogunin ring finger 1
  makorin ring finger protein 3
  marginal zone B and B1 cell specific protein
  metastasis associated 1 family member 3
  multivesicular body subunit 12A
  multivesicular body subunit 12B
  NGG1 interacting factor 3 like 1
  N-myc downstream regulated 1
  nuclear FMR1 interacting protein 2
  nuclear RNA export factor 1
  palladin, cytoskeletal associated protein
  PBX/knotted 1 homeobox 2
  PDZ and LIM domain 7
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  PPFIA binding protein 2
  PR/SET domain 16
  programmed cell death 6
  programmed cell death 6 interacting protein
  prominin 1
  protein inhibitor of activated STAT 1
  protein phosphatase 1 regulatory subunit 13B
  protein tyrosine phosphatase non-receptor type 23
  protein tyrosine phosphatase, non-receptor type 23
  QKI, KH domain containing RNA binding
  RAB11 family interacting protein 3
  RAB11 family interacting protein 4
  RAB7A, member RAS oncogene family
  RAB9A, member RAS oncogene family
  RAD18 E3 ubiquitin protein ligase
  RAS like family 10 member B
  ring finger protein 111
  ring finger protein 126
  ring finger protein 41
  RNA binding protein, mRNA processing factor
  scavenger receptor class A member 5
  SEC16 homolog A, endoplasmic reticulum export factor
  SEC23 interacting protein
  SEC24 homolog B, COPII coat complex component
  secretoglobin family 3A member 1
  secretory carrier membrane protein 3
  serine protease 50
  SH3 domain containing GRB2 like, endophilin B2
  SH3 domain containing kinase binding protein 1
  signal transducing adaptor molecule 2
  SNAP associated protein
  SNF8 subunit of ESCRT-II
  sorting nexin 32
  spastin
  structural maintenance of chromosomes flexible hinge domain containing 1
  synaptonemal complex central element protein 1
  tankyrase 1 binding protein 1
  target of myb1 like 1 membrane trafficking protein
  target of myb1 membrane trafficking protein
  TatD DNase domain containing 1
  Tax1 binding protein 1
  testis expressed 11
  TNFAIP3 interacting protein 1
  TNFAIP3 interacting protein 2
  TRAF interacting protein
  trafficking from ER to golgi regulator
  tripartite motif containing 25
  tripartite motif containing 35
  tripartite motif containing 46
  tripartite motif containing 47
  tripartite motif containing 54
  tripartite motif containing 74
  tripartite motif family like 2
  tryptophanyl-tRNA synthetase 1
  tuftelin interacting protein 11
  tumor susceptibility 101
  ubiquitin A-52 residue ribosomal protein fusion product 1
  ubiquitin associated protein 1
  ubiquitin C
  ubiquitin conjugating enzyme E2 I
  UHRF1 binding protein 1
  USH1 protein network component harmonin binding protein 1
  vacuolar protein sorting 28
  vacuolar protein sorting 36 homolog
  valosin containing protein
  vasodilator stimulated phosphoprotein
  VPS11 core subunit of CORVET and HOPS complexes
  VPS28 subunit of ESCRT-I
  VPS37A subunit of ESCRT-I
  VPS37B subunit of ESCRT-I
  VPS37C subunit of ESCRT-I
  VPS37D subunit of ESCRT-I
  WASH complex subunit 1
  WD repeat domain 12
  WD repeat domain 26
  WD repeat domain 5
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  zinc finger FYVE-type containing 9
  ZW10 interacting kinetochore protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.