TRPV1, transient receptor potential cation channel subfamily V member 1

TRPV1, transient receptor potential cation channel subfamily V member 1

• Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (transient receptor potential cation channel subfamily V member 1, OTRPC1, capsaicin receptor, osm-9-like TRP channel 1, transient receptor potential vanilloid 1a, transient receptor potential vanilloid 1b, vanilloid receptor subtype 1, VR1,)
• NCBI Gene ID: 7442
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8NER1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transient receptor potential cation channel subfamily V member 1 interacts with:

• A-kinase anchoring protein 5
  itchy E3 ubiquitin protein ligase
  OS9 endoplasmic reticulum lectin
  SNAP associated protein
  synaptotagmin 9
  transient receptor potential cation channel subfamily V member 1
  transient receptor potential cation channel subfamily V member 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.