RNF34, ring finger protein 34

RNF34, ring finger protein 34

• The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

• Gene Synonyms (E3 ubiquitin-protein ligase RNF34, FYVE-RING finger protein MOMO, RING finger protein RIFF, RING-type E3 ubiquitin transferase RNF34, caspase regulator CARP1, caspases-8 and -10-associated RING finger protein 1, human RING finger homologous to inhibitor of apoptosis protein, ring finger protein 34, E3 ubiquitin protein ligase, CARP-1, CARP1, RFI, RIF, RIFF, hRFI,)
• NCBI Gene ID: 80196
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q969K3
  UNIPROT ID#>>A0A087WTM5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 34 interacts with:

• DDB1 and CUL4 associated factor 15
  EF-hand calcium binding domain 7
  kelch like family member 15
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  TSR3 ribosome maturation factor
  ubiquitin conjugating enzyme E2 F (putative)
  unc-119 lipid binding chaperone B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.