LGI1, leucine rich glioma inactivated 1

LGI1, leucine rich glioma inactivated 1

• This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

• Gene Synonyms (leucine-rich glioma-inactivated protein 1, epitempin-1, ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099,)
• NCBI Gene ID: 9211
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z5G1
  UNIPROT ID#>>A0A0S2Z4S7
  UNIPROT ID#>>A0A0S2Z4X3
  UNIPROT ID#>>O95970
  UNIPROT ID#>>A0A1B0GUD3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

leucine rich glioma inactivated 1 interacts with:

• ADAM metallopeptidase domain 22

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.