ARHGEF10, Rho guanine nucleotide exchange factor 10

ARHGEF10, Rho guanine nucleotide exchange factor 10

• This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

• Gene Synonyms (rho guanine nucleotide exchange factor 10, Rho guanine nucleotide exchange factor (GEF) 10, GEF10, SNCV,)
• NCBI Gene ID: 9639
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15013
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho guanine nucleotide exchange factor 10 interacts with:

• Bet1 golgi vesicular membrane trafficking protein
  CD2 associated protein
  COBW domain containing 3
  coiled-coil domain containing 88A
  COPI coat complex subunit gamma 1
  DnaJ heat shock protein family (Hsp40) member B5
  peptidyl-tRNA hydrolase 2
  proteasome activator subunit 4
  ring finger and SPRY domain containing 1
  ring finger protein 31
  SET domain containing 2, histone lysine methyltransferase
  single stranded DNA binding protein 2
  splA/ryanodine receptor domain and SOCS box containing 2
  spliceosome associated factor 3, U4/U6 recycling protein
  trans-golgi network protein 2
  vir like m6A methyltransferase associated
  WD repeat domain 48

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.