KIAA0100, KIAA0100

KIAA0100, KIAA0100

• This gene was initially characterized in human as having high expression levels in breast carcinomas and breast cancer cell lines. This gene also has increased expression in prostrate cancer cells relative to normal prostrate tissues. Expression of this gene is negatively regulated by direct binding of the microRNA miR-195 to its 3' UTR. miR-195 has been shown to modulate the invasiveness of prostrate cancer cells and xenograft metastases by downgrading expression of this gene. In mouse, the protein encoded by this gene was identified as an antigen on acute monocytic leukemia cells. In human, alternative splicing results in multiple transcript variants encoding distinct isoforms; some of these isoforms are predicted to contain an RNA pol II promoter FMP27 protein domain and a Golgi-body-localization APT1 domain. [provided by RefSeq, Apr 2017]

• Gene Synonyms (protein KIAA0100, U937-associated antigen, antigen MLAA-22, breast cancer overexpressed gene 1, breast cancer-overexpressed gene 1 protein, cancer/testis antigen 101, BCOX, BCOX1, CT101, FMP27,)
• NCBI Gene ID: 9703
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14667
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

KIAA0100 interacts with:

• dedicator of cytokinesis 5
  pleckstrin homology domain containing A4
  ring finger protein 126
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.