DUX4, double homeobox 4

DUX4, double homeobox 4

• This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

• Gene Synonyms (DUX4L, double homeobox protein 4, double homeobox 4-like, double homeobox protein 10, double homeobox protein 4/10,)
• NCBI Gene ID: 100288687
• Species: Homo sapiens (Human)
• UNIPROT ID#>>E2JJS1
  UNIPROT ID#>>C3U3A0
  UNIPROT ID#>>Q9UBX2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

double homeobox 4 interacts with:

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