PARP2, poly(ADP-ribose) polymerase 2

PARP2, poly(ADP-ribose) polymerase 2

• This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]

• Gene Synonyms (poly [ADP-ribose] polymerase 2, ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2, ADP-ribosyltransferase diphtheria toxin-like 2, ADPRT-2, DNA ADP-ribosyltransferase PARP2, NAD(+) ADP-ribosyltransferase 2, hPARP-2, poly (ADP-ribose) polymerase family, member 2, poly (ADP-ribosyl) transferase-like 2, poly[ADP-ribose] synthase 2, poly[ADP-ribose] synthetase 2, protein poly-ADP-ribosyltransferase PARP2, ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2,)
• NCBI Gene ID: 10038
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UGN5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

poly(ADP-ribose) polymerase 2 interacts with:

• aprataxin and PNKP like factor
  bromodomain containing 7
  chromobox 5
  cyclic GMP-AMP synthase
  forkhead box B1
  H2B clustered histone 1
  histone PARylation factor 1
  LIM homeobox 9
  macroH2A.2 histone
  mono-ADP ribosylhydrolase 1
  N-alpha-acetyltransferase 40, NatD catalytic subunit
  nucleophosmin 1
  proteasome (prosome, macropain) subunit, beta type 5
  RAD18 E3 ubiquitin protein ligase
  replication protein A4
  ring finger protein 146
  sirtuin 6
  spindlin family member 2B
  TNFAIP3 interacting protein 2
  tripartite motif containing 28
  ubiquitin like with PHD and ring finger domains 1
  visual system homeobox 2
  WD repeat domain 76
  zinc finger protein 428

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.