NET1, neuroepithelial cell transforming 1

NET1, neuroepithelial cell transforming 1

• This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

• Gene Synonyms (ARHGEF8, NET1A, neuroepithelial cell-transforming gene 1 protein, Rho guanine nucleotide exchange factor (GEF) 8, epididymis secretory sperm binding protein, guanine nucleotide regulatory protein (oncogene), neuroepithelioma transforming gene 1, p65 Net1 proto-oncogene protein, small GTP-binding protein regulator,)
• NCBI Gene ID: 10276
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5SQI5
  UNIPROT ID#>>Q5SQI7
  UNIPROT ID#>>Q7Z628
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

neuroepithelial cell transforming 1 interacts with:

• calcium/calmodulin-dependent serine protein kinase (MAGUK family)
  discs large MAGUK scaffold protein 1
  discs large MAGUK scaffold protein 3
  discs large MAGUK scaffold protein 4
  lin-7 homolog C (C. elegans)
  membrane associated guanylate kinase, WW and PDZ domain containing 1
  membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
  membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
  N-terminal glutamine amidase 1
  TNFAIP3 interacting protein 2
  WD repeat domain 83

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.