RNASEH2A, ribonuclease H2 subunit A

RNASEH2A, ribonuclease H2 subunit A

• The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]

• Gene Synonyms (AGS4, JUNB, RNASEHI, RNHIA, RNHL, THSD8, ribonuclease H2 subunit A, RNase H(35), RNase H2 subunit A, RNase HI large subunit, aicardi-Goutieres syndrome 4 protein, ribonuclease H2, large subunit, ribonuclease HI large subunit, ribonuclease HI subunit A,)
• NCBI Gene ID: 10535
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75792
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ribonuclease H2 subunit A interacts with:

• 1-acylglycerol-3-phosphate O-acyltransferase 1
  2,4-dienoyl-CoA reductase 2
  chromosome 19 open reading frame 47
  chromosome 6 open reading frame 141
  component of oligomeric golgi complex 2
  dedicator of cytokinesis 6
  DNA polymerase delta interacting protein 3
  family with sequence similarity 136 member A
  F-box and WD repeat domain containing 11
  forty-two-three domain containing 1
  intelectin 1
  isoleucyl-tRNA synthetase 2, mitochondrial
  kaptin, actin binding protein
  kelch like family member 36
  MAM domain containing 2
  N-6 adenine-specific DNA methyltransferase 1
  NADPH dependent diflavin oxidoreductase 1
  oxysterol binding protein 2
  partner and localizer of BRCA2
  PHD finger protein 20 like 1
  proline and serine rich coiled-coil 1
  ribonuclease H2 subunit B
  ribonuclease H2 subunit C
  SET domain containing 3, actin histidine methyltransferase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.