P3H3, prolyl 3-hydroxylase 3

P3H3, prolyl 3-hydroxylase 3

• The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013]

• Gene Synonyms (GRCB, HSU47926, LEPREL2, prolyl 3-hydroxylase 3, gene rich cluster, B, leprecan-like 2, procollagen-proline 3-dioxygenase, protein B,)
• NCBI Gene ID: 10536
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IVL6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

prolyl 3-hydroxylase 3 interacts with:

• C1q and TNF related 2
  C1q and TNF related 9
  keratin associated protein 12-3
  keratin associated protein 1-3
  keratin associated protein 9-2
  kirre like nephrin family adhesion molecule 2
  olfactomedin 4
  OS9 endoplasmic reticulum lectin
  transmembrane protein 25
  WW domain containing E3 ubiquitin protein ligase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.