TMED10, transmembrane p24 trafficking protein 10

TMED10, transmembrane p24 trafficking protein 10

• This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

• Gene Synonyms (P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1, transmembrane emp24 domain-containing protein 10, 21 kDa transmembrane trafficking protein, p24 family protein delta-1, p24delta, p24delta1, testicular tissue protein Li 206, transmembrane emp24-like trafficking protein 10, transmembrane protein Tmp21,)
• NCBI Gene ID: 10972
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P49755
  UNIPROT ID#>>A0A024R6I3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transmembrane p24 trafficking protein 10 interacts with:

• ankyrin repeat and SOCS box containing 8
  aph-1 homolog A, gamma-secretase subunit
  calreticulin 3
  caveolae associated protein 1
  CDKN2A interacting protein
  COPI coat complex subunit epsilon
  COPI coat complex subunit gamma 1
  COPI coat complex subunit gamma 2
  COPI coat complex subunit zeta 1
  dual specificity phosphatase 26
  egl-9 family hypoxia inducible factor 3
  ER membrane protein complex subunit 7
  F-box protein 6
  F-box protein 7
  golgi reassembly stacking protein 1
  golgi reassembly stacking protein 2
  integrin alpha FG-GAP repeat containing 1
  ligand of numb-protein X 1
  limb development membrane protein 1 like
  nicastrin
  nitrilase family member 2
  nucleotide binding oligomerization domain containing 2
  pleckstrin homology domain containing A4
  potassium channel tetramerization domain containing 12
  presenilin enhancer, gamma-secretase subunit
  S100 calcium binding protein A16
  solute carrier family 15 member 3
  tectonic family member 1
  transmembrane p24 trafficking protein 1
  transmembrane p24 trafficking protein 2
  transmembrane p24 trafficking protein 3
  transmembrane p24 trafficking protein 4
  transmembrane p24 trafficking protein 5
  transmembrane p24 trafficking protein 7
  transmembrane p24 trafficking protein 9
  transmembrane protein 41B
  USO1 vesicle docking factor
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.