ARHGEF25, Rho guanine nucleotide exchange factor 25

ARHGEF25, Rho guanine nucleotide exchange factor 25

• Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

• Gene Synonyms (GEFT, p63RhoGEF, rho guanine nucleotide exchange factor 25, RAC/CDC42 exchange factor, Rho guanine nucleotide exchange factor (GEF) 25, RhoA/RAC/CDC42 exchange factor, guanine nucleotide exchange factor GEFT, rac/Cdc42/Rho exchange factor GEFT, rhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT,)
• NCBI Gene ID: 115557
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q86VW2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho guanine nucleotide exchange factor 25 interacts with:

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.