- Gene Overview
- Interaction Network
- Sequence Verification
NLRP4, NLR family pyrin domain containing 4
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The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]
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Gene Synonyms (CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2, NACHT, LRR and PYD domains-containing protein 4, NACHT, leucine rich repeat and PYD containing 4, PAAD and NACHT-containing protein 2, PYRIN and NACHT-containing protein 2, PYRIN-containing APAF1-like protein 4, cancer/testis antigen 58, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4, ribonuclease inhibitor 2,)
- NCBI Gene ID:
147945
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>B2RCA1
UNIPROT ID#>>Q96MN2
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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NLR family pyrin domain containing 4 interacts with:
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