CCN2, cellular communication network factor 2

CCN2, cellular communication network factor 2

• The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]

• Gene Synonyms (CCN family member 2, IBP-8, IGF-binding protein 8, IGFBP-8, connective tissue growth factor, hypertrophic chondrocyte-specific protein 24, insulin-like growth factor-binding protein 8, CTGF, HCS24, IGFBP8, NOV2,)
• NCBI Gene ID: 1490
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5M8T4
  UNIPROT ID#>>P29279
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cellular communication network factor 2 interacts with:

• adaptor related protein complex 3 subunit delta 1
  ariadne RBR E3 ubiquitin protein ligase 1
  cellular communication network factor 3
  cytochrome c oxidase assembly factor 7 (putative)
  E1A binding protein p300
  ELAV like RNA binding protein 1
  epidermal growth factor receptor
  erb-b2 receptor tyrosine kinase 4
  fibulin 1
  fizzy and cell division cycle 20 related 1
  heparan sulfate proteoglycan 2
  kelch like family member 23
  LDL receptor related protein 1
  LDL receptor related protein 2
  metadherin
  transforming growth factor beta 1
  transforming growth factor beta 2
  transforming growth factor beta 3
  tripartite motif containing 68
  vascular endothelial growth factor A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.