- Gene Overview
- Interaction Network
- Sequence Verification
DEFA3, defensin alpha 3
-
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. [provided by RefSeq, Oct 2014]
-
Gene Synonyms (neutrophil defensin 3, defensin 3, neutrophil-specific, defensin, alpha 3, neutrophil-specific, neutrophil peptide 3, DEF3, HNP-3, HNP3, HP-3, HP3,)
- NCBI Gene ID:
1668
- Species:
Homo sapiens (Human)
-
UNIPROT ID#>>P59666
UNIPROT ID#>>Q6EZE9
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
defensin alpha 3 interacts with:
Paste a protein or nucleic acid sequence in the box below to confirm that it matches
this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
how a sequence matches to an experimentally-validated ORF clone.
|