- Gene Overview
- Interaction Network
- Sequence Verification
ADAMTS18, ADAM metallopeptidase with thrombospondin type 1 motif 18
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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016]
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Gene Synonyms (A disintegrin and metalloproteinase with thrombospondin motifs 18, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21, disintegrin and metalloprotease-like protein, ADAMTS21, KNO2, MMCAT,)
- NCBI Gene ID:
170692
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q2VYF7
UNIPROT ID#>>Q8TE60
UNIPROT ID#>>Q6ZN25
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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ADAM metallopeptidase with thrombospondin type 1 motif 18 interacts with:
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